COMPOSITION COMPRENANT UN EXTRAIT DE FRUIT DE ROSA MULTIFLORA TRAITÉ PAR ENZYME EN TANT QUE SUBSTANCE ACTIVE POUR PRÉVENIR OU TRAITER UNE MALADIE IMMUNOLOGIQUE MÉDIÉE PAR TH2
SHON, Dong-Hwa,손동화,EOM, Ji Eun,엄지은,SHIN, Hee Soon,신희순,DO, Jeong-Ryong,도정룡,LEE, So Young,이소영,CHOI, Dae Woon,최대운,JUNG, Sun Young,정선영,SEE, Hye-Jeong,시혜정,KWON, Da-Ae,권다애,BACK, Su Yeon,백수연
申请号：
KRKR2016/013971
公开号：
WO2017/099413A1
申请日:
2016.11.30
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a composition comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient for preventing or treating a Th2-mediated immune disease. The composition according to the present invention can maximize the anti-allergic effect of the Rosa multiflora fruit extract by comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient. Specifically, the present inventors verified that, as a result of treating splenocytes of OVA-immunized mice with an enzyme-treated Rosa multiflora fruit extract, the enzyme-treated Rosa multiflora fruit extract remarkably promoted IL-4 production inhibitory activity compared with an enzyme-non-treated Rosa multiflora fruit extract and the in vivo oral administration of the enzyme-treated Rosa multiflora fruit extract remarkably reduced the blood IgE content in the OVA-immunized mice. In addition, the composition according to the present invention has advantages of being biocompatible and having excellent stability due to the use of Rosa multiflora fruit as a natural material, and thus, the composition is expected to be favorably used in the development of a safe therapeutic agent, a health functional food, a cosmetic product, and the like for the prevention, improvement, or treatment of a Th2-mediated immune disease.La présente invention concerne une composition comprenant un extrait de fruit de Rosa multiflora traité par enzyme en tant que substance active pour prévenir ou traiter une maladie immunitaire médiée par Th2. La composition selon la présente invention peut maximiser l'effet antiallergique de l'extrait de fruit de Rosa multiflora en incluant un extrait de fruit de Rosa multiflora traité par enzyme en tant que substance active. Spécifiquement, les présents inventeurs ont vérifié que, en conséquence du traitement de splénocytes de souris immunisées par OVA avec un extrait de fruit de Rosa multiflora traité par enzyme, l'extrait de fruit de Rosa multiflora traité
