BARTOLOZZI, ALESSANDRA,OLAGUE, ALAN,BOSANAC, TODD,CHEN, ZHIDONG,DE LOMBAERT, STEPHANE,HUBER, JOHN D.,LO, HO-YIN,LOKE, PIU LENG,LIU, WEIMIN,MORWICK, TINA MARIE,RIETHER, DORIS,TYE, HEATHER,WU, LIFEN,ZIN
申请号：
PE0002792013
公开号：
PE07512013A1
申请日:
2011.08.11
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Oxadiazoles derivatives relates to compounds of formula (i) wherein R1 and R2 are each h, alkyl (C1 - C7) or carbociclo (C3 - C10) R3 is heteroaryl 5 to 11 members optionally substituted with alkoxy (C1 - C5) - benzyl, halogen, or R4, among others is H, alkyl, Halogen (C1 - C3) or Nitrile R5 is alq Uilo (C1 - C6), carbociclo (C3 - C10), heterocycle aryl 3 to 11 members, among others.Preferred compounds are: 2 - (3 - (2 - [4 - (5 - metoxipiridin - 3 - il) phenyl] - 3 - metilbutan - il - 2} - 1,2,4 - Oxadiazoles - 5 - il) pyrazine 5 - (4 - [3 - (2 - methyl - 5 - phenyl 1,2,4 - Oxadiazoles - 3 - il) butan-2-ol - il - 2}] pyrimidine phenyl Amine, 5 - (4 - (3 - methyl - 2 - [4 - (pyridin-3-yl) - 1,2,4 - Oxadiazoles - 3 - Il Il}] Bhutan - 2 - phenyl - 2 - pyrimidin-2-yl) Amine among others. You. It also relates to a Pharmaceutical composition.These compounds are inhibitors of the 5-lipoxygenase Activating Protein (flap) is useful in the treatment of Asthma, allergies, rheumatoid arthritis, multiple sclerosis, atherosclerosisSE REFIERE A COMPUESTOS DERIVADOS DE OXADIAZOL DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C7) O CARBOCICLO(C3-C10) R3 ES HETEROARILO DE 5 A 11 MIEMBROS OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C5), HALOGENO, -O-BENCILO, ENTRE OTROS R4 ES H, ALQUILO(C1-C3), HALOGENO O NITRILO R5 ES ALQUILO(C1-C6), CARBOCICLO(C3-C10), HETEROCICLO DE 3 A 11 MIEMBROS, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(3-{2-[4-(5-METOXIPIRIDIN-3-IL)FENIL]-3-METILBUTAN-2-IL}-1,2,4-OXADIAZOL-5-IL)PIRAZINA 5-{4-[3-METIL-2-(5-FENIL-1,2,4-OXADIAZOL-3-IL)BUTAN-2-IL]FENIL}PIRIMIDIN-2-AMINA 5-(4-{3-METIL-2-[5-(PIRIDIN-3-IL)-1,2,4-OXADIAZOL-3-IL]BUTAN-2-IL}FENIL)PIRIMIDIN-2-AMINA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA ACTIVADORA DE LA 5-LIPOXIGENASA (FLAP) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, ALERGIA, ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE, ATEROSCLEROSIS
