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Substituted tetrahydronaphthalenes, process for their preparation and use and use as medicines
专利权人:
SANOFI-AVENTIS
发明人:
LOTHAR SCHWINK,SIEGFRIED STENGELIN,MATTHIAS GOSSEL,TORSTEN HAACK,PETRA LENNIG
申请号:
BRPI0815206
公开号:
BRPI0815206A2
申请日:
2008.08.14
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
Substituted benzene compounds (I) and their salts, are new. Substituted benzene compounds of formula (I) and their salts, are new. Either R 1>;, R 2>;H, (1-8C)-alkyl, (1-4C)-alkoxy-(1-4C)-alkyl, (3-8C)-alkenyl, (3-8C)-alkynyl, CO(R 9>;), (C(R 1>; 0>;)(R 1>; 1>;)) q-R 1>; 2>;, CO(C(R 1>; 3>;)(R 1>; 4>;)) rR 1>; 5>;, COO(1-8C)-alkyl or CO(C(R 1>; 3>;)(R 1>; 4>;)) rN(R 1>; 6>;)(R 1>; 7>;); and L 1>;C(R 3>; 4>;)(R 3>; 5>;), C(R 3>; 6>;)(R 3>; 7>;)C(R 3>; 8>;)(R 3>; 9>;) or (3-6C)-cycloalkyl; and R 3>; 4>;-R 3>; 9>;H or (1-8C)-alkyl; or R 1>;R 2>;N : 4-10-membered mono-, bi- or spiro-cyclic ring (which additionally contains 0-3 heteroatoms except N, preferably O, N or S), where the heterocyclic ring system is additionally substituted by F, Cl, Br, CF 3, CN, (1-6C)-alkyl, (3-8C)-cycloalkyl, O-(1-8C)-alkyl, (1-4C)-alkoxy-(1-4C)-alkyl, hydroxy-(1-6C)-alkyl, oxo, CO(R 1>; 8>;), CON(R 1>; 9>;)(R 2>; 0>;), OH, COO(R 2>; 1>;), N(R 2>; 2>;)CO(1-6C)-alkyl, N(R 2>; 3>;)(R 2>; 4>;) or SO 2(1-6C)-alkyl; or R 1>;R 3>; 4>;, R 1>;R 3>; 5>;, R 1>;R 3>; 6>;, R 1>;R 3>; 7>;, R 1>;R 3>; 8>;, R 1>;R 3>; 9>;5-6-membered ring; R 1>; 0>;, R 1>; 1>;H, (1-6C)-alkyl, hydroxy-(1-2C)-alkyl, F or OH; either R 9>;, R 1>; 3>;, R 1>; 4>;, R 1>; 6>;, R 1>; 7>;-R 2>; 4>;H or (1-6C)-alkyl; or R 1>; 6>;R 1>; 7>;N, R 2>; 3>;R 2>; 4>;N : 5-6 membered ring, which can include further 0-1 heteroatoms except N, which are NH, N-(1-6C)-alkyl, O or S; q, r : 0-6; R 1>; 2>;, R 1>; 5>;H, OH, F, O-(1-6C)-alkyl, S-(1-6C)-alkyl, O-phenyl, CN, COO(R 2>; 5>;), N(R 2>; 6>;)CO(1-6C)-alkyl, N(R 2>; 7>;)(R 2>; 8>;), CON(R 2>; 9>;)(R 3>; 0>;), SO 2(1-6C)-alkyl, 3-12-membered mono-, bi- or spiro-cyclic ring (containing 4 heteroatoms of N, O or S, and further substituted by F, Cl, Br, OH, CF 3, NO 2, CN, OC
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