Eliglustat (GENZ 112638) kot inhibitor sintaze glukozilceramida za uporabo v postopku zdravljenja Fabrjyeve ali Gaucherjeve bolezni, kjer postopek obsega prilagajanje individualnega terapevtskega odmerka metabolizmu P-450 pacienta
LIU Hanlan,WILLIS Chris,BHARDWAJ Renu,COPELAND Diane P.,HARIANAWALA Abizer,SKELL Jeffrey,MARSHALL John,KOCHLING Jianmei,PALACE Gerard,PETERSCHMITT Judith,SIEGEL Craig,CHENG Seng
申请号：
SI201031936
公开号：
SI3133070T1
申请日:
2010.11.24
申请国别(地区):
SI
年份:
2019
代理人:
摘要：
The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
