Alison E. McGonagle,Allan M. Jordan,Bohdan Waszkowycz,Colin P. Hutton,Ian D. Waddell,James R. Hitchin,Kate M. Smith,Niall M. Hamilton
申请号：
US15533819
公开号：
US10508086B2
申请日:
2015.12.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
