The present invention provides a pharmaceutical composition for treating cardiovascular disorders comprising 3-1 portion echinocystic acid and 1 portion oleanolic acid as the active components. The present invention also provides a gleditsiae extract comprising echinocystic acid and oleanolic acid of 90.0%-99.9% total weight, wherein the weight ratio of echinocystic acid and oleanolic acid is 3:1-1:3. The preparation method and use of the extract are also provided in the present invention. The pharmaceutical composition in the present invention degrades hepatotoxicity by controlling the ratio of echinocystic acid and oleanolic acid in the composition.
