The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor； and (b) a foamable carrier comprising:i. about 50% to about 98% of a solvent selected from the group consisting of water； a hydrophilic solvent； a hydrophobic solvent； a potent solvent； a polar solvent, a silicone, an emollient, and mixtures thereof；ii. 0% to about 48% of a secondary solvent selected from the group consisting of water； a hydrophilic solvent； a hydrophobic solvent； a potent solvent； a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof；iii. a surface-active agent；iv. about 0% to about 5% by weight of at least one polymeric agent； andv. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition；wherein the composition is housed in a container and is substantially flowable, andwhich upon release expands to form a breakable foam； andwherein the foamable carrier is selected to generate a foam of good to excellent quality.The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
