Martyn Frederickson;Andrew James Woodhead;Christopher Murray;Robert Downha;Michael Alistair O'Brien;Miles Stuart Congreve;Eva Figueroa Navarro;Maria Grazia Carr;Gianni Chessari;Alison Jo-Anne Woolford
发明人:
Gianni Chessari,Miles Stuart Congreve,Eva Figueroa Navarro,Martyn Frederickson,Christopher Murray,Alison Jo-Anne Woolford,Maria Grazia Carr,Michael Alistair O'Brien,Andrew James Woodhead,Robert Downha,Michael Alistair OBrien,Robert Downham
申请号：
US11911490
公开号：
US08101648B2
申请日:
2006.04.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compounds of the formula (I):or salts, tautomers, solvates and N-oxides thereof； wherein R1 is hydrogen； R2 is hydroxy or methoxy； R3 is selected from hydrogen； halogen； cyano； optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy； R4 is selected from hydrogen； a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members； halogen； cyano； hydroxy； amino； and optionally substituted mono- or di-C1-5 hydrocarbyl-amino； or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members； and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.
