Compound, use, anti-tumor pharmaceutical composition, gene construct for polypeptide expression, process for the production, process for the evaluation of tumor cells, method of sensitization of tumor cells to chemotherapeutic
mantendedora da PUCRS;União Brasileira de Educaçâo e Assistência
发明人:
Cristina Beatriz Cazabuena Bonorino,Ana Paula Duarte de Souza
申请号：
US14655608
公开号：
US10508139B2
申请日:
2013.12.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. A gene construct for the expression of said protein； a production process； a process of evaluation of tumor cells； and a method of sensitization of tumors to chemotherapeutic agents. A new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells, in part as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.
