KIM YONG SUNG,CHOI DONG KI,SHIN SEUNG MIN,KIM SUNG HOON
申请号：
IN201747004164
公开号：
IN201747004164A
申请日:
2017.02.06
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to a method for positioning in a cytoplasm an antibody having a complete immunoglobulin form by means of active cell penetration. In addition the present invention relates to a light chain variable region (VL) that induces the active penetration of a cell membrane of a living cell by an antibody having a complete immunoglobulin form and the positioning of the antibody in the cytoplasm and an antibody comprising same. Also the present invention relates to a bioactive molecule fused to the antibody. Also the present invention relates to a composition for preventing treating or diagnosing cancer comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes the light chain variable region and the antibody. The present invention also relates to a method for preparing an antibody that is made to penetrate through to the inside of a cell and positioned in the cytoplasm.
