КИМ Дзонг-Моок (KR),КИМ Судзеонг (KR),ХАН Воонг (KR)
申请号：
RU2010135532/10
公开号：
RU2010135532A
申请日:
2009.01.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The use of a composition comprising an effective amount of two or more isoforms of HGF or one or more polynucleotides encoding isoforms for the manufacture of a medicament for treating or preventing heart disease in a subject, wherein said HGF isoforms include full-length hepatocyte growth factor (flHGF) and a factor variant hepatocyte growth with deletion (dHGF). ! 2. The use according to claim 1, wherein the treatment or prevention of heart disease occurs by increasing the perfusion or density of capillaries of heart tissue in a subject. ! 3. The use according to claim 2, wherein the heart tissue is ischemic heart tissue. ! 4. The use according to claim 1, in which the treatment or prevention of heart disease occurs by enhancing the restoration of the endothelium at the site of damage to the vessel or the affected vessel in the subject. ! 5. The use of a composition comprising an effective amount of two or more isoforms of HGF or one or more polynucleotides encoding isoforms for the manufacture of a medicament for activating endothelial cell growth in a blood vessel, wherein said HGF isoforms include full-size hepatocyte growth factor (flHGF) and a variant factor hepatocyte growth with deletion (dHGF). ! 6. The use according to claim 5, in which the blood vessel is damaged. ! 7. The use according to claim 6, wherein the re-endothelization of said blood vessel is activated or accelerated. ! 8. The use of claim 5, wherein the blood vessel is in a subject in need of prevention or treatment of restenosis. ! 9. The use according to any one of claims 1 to 8, in which two or more isoforms of HGF is introduced in the form of polynuclei1. Применение композиции, включающей эффективное количество двух или более изоформ HGF или одного или нескольких полинуклеотидов, кодирующих изоформы, для производства лекарственного средства для лечения или предупреждения болезни сердца у субъекта, где указанные изоформы HGF включают полноразмерный фактор роста гепатоцитов (flHGF) и вари
