Balu Paulose Maliakel;Aswin Koshy Jacob Vaidyan;Krishnakumar Illathu Madhavamenon;Abin Isaac;Dineshkumar Unnikrishnan
发明人:
Krishnakumar Illathu Madhavamenon,Abin Isaac,Dineshkumar Unnikrishnan,Aswin Koshy Jacob Vaidyan,Balu Paulose Maliakel
申请号：
US13562337
公开号：
US09861610B2
申请日:
2012.07.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers of the type A and type B, of more than 90% purity as gallic acid equivalent which comprises the steps of removing the organic solvent from the extract to produce the free flowing oleoresin and drying of the residue under optimized conditions to produce a polyphenol and procyanidin Type A & B polymer rich solid which on subsequent extraction with water or with mixture of water and acetone or water and lower alcohol and further evaporation to a solid content of not more than 6% and subsequent chromatographic separation to obtain fractions containing procyanidin type A and B polymers free of coumarins and cinnamaldehyde. The present invention also relates to stable composition comprising cinnamon polyphenol rich powder for delivering maximum bioactivity upon oral administration.
