urea compounds and their use as enzyme inhibitors

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专利权人:

BIAL - PORTELA & Cª; S.A

发明人:

Carla Patrícia da Costa Pereira ROSA,LASZLO ERNO KISS,Rita GUSMÃO DE NORONHA,Rui PINTO

申请号：

BR112016002196

公开号：

BR112016002196A2

申请日:

2014.08.01

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

Patent Summary for: "Urea Compounds and Their Use as Enzyme Inhibitors". a compound having the formula I: wherein: R1 is selected from hydrogen, halogen, hydroxyl and C1-4 alkoxy； R 2 is selected from hydrogen, halogen, hydroxy and C 1-4 alkoxy； R3 is C1-4 alkyl； r4 is aryl, which is substituted with a group selected from oso2nh2, nhconh2, nhso2nh2, nhso2alkyl c1-4 and meet2； and n is 0 or 1； or a pharmaceutically acceptable salt thereof； provided that the compound is not n- (1-benzylpiperidin-4-yl) -n-methyl-4- (4- (sulfamoylamino) phenyl) -1h-imidazole-1-carboxamide or n- (1-benzylpiperidin-4-yl) -N-methyl-4- (3- (methylsulfonamido) phenyl) -1h-imidazole-1-carboxamide. The compound may be used as a fatty acid amide hydrolase inhibitor.resumo da patente de invenã§ã£o para: “compostos de ureia e sua utilizaã‡ãƒo como inibidores enzimã�ticosâ€�. um composto possuindo a fã³rmula i: fã³rmula i em que: r1 ã© seleccionado de hidrogã©nio, halogã©neo, hidroxilo e alcoxilo c1-4； r2 ã© seleccionado de hidrogã©nio, halogã©neo, hidroxilo e alcoxilo c1-4； r3 ã© alquilo c1-4； r4 ã© arilo, o qual estã¡ substituã­do com um grupo seleccionado de oso2nh2, nhconh2, nhso2nh2, nhso2alquilo c1-4 e conh2； e n ã© 0 ou 1； ou um seu sal farmaceuticamente aceitã¡vel； na condiã§ã£o de que o composto nã£o seja n-(1-benzilpiperidin-4-il)-n-metil-4-(4-(sulfamoilamino)-fenil)-1h-imidazole-1-carboxamida ou n-(1-benzilpiperidin-4-il)-n-metil-4-(3-(metilsulfonamido)fenil)-1h-imidazole-1-carboxamida. o composto pode ser utilizado como um inibidor da hidrolase de amidas de ã¡cidos gordo.

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