PARK, YOUNG JUN,박영준,JEONG, JIN KYO,정진교,CHOI, YOUNG MI,최영미,LEE, MIN SEOB,이민섭,CHO, YU YOUNG,조유영,KIM, YEON JUNG,김연정,CHOI, JOON HUN,최준헌,LEE, JIN SEO,이진서,CHO, EUN JOO,조은주,SONG, HYUN NAM,송현남,PARK, SUNG JUN,PARK, YOUNG JUNKR,JEONG, JIN KYOKR,CHOI, YOUNG MIKR,LEE, MIN SEOBKR,CHO, YU YOUNGKR,KIM, YEON JUNGKR,CHOI, JOON HUNKR,LEE, JIN SEOKR,CHO, EUN JOOKR,SONG, HYUN NAMKR
申请号：
KR1020130017585
公开号：
KR1020140088828A
申请日:
2013.02.19
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to an antibody-linker-drug conjugate having an excellent anti-cancer activity, a preparation method thereof, and an anti-cancer agent composition containing the same as an active ingredient. In particular, in the antibody-linker-drug conjugate, the antibody and the cytotoxic drug are conjugated by the catalyst-decomposition type peptide linker, which can be directly bound to a lysine residue of the antibody.본 발명은 항체의 라이신 잔기에 직접 결합할 수 있는 효소-분해형 펩타이드 링커를 통해 항체와 세포독성 약물이 접합된 항체-링커-약물 결합체, 그의 제조방법 및 그를 유효성분으로 포함하는 항암제 조성물을 제공한다.
