The present invention provides 4H, 6H-5-oxa-2, 3, 10b-triaza-benzo[e]azulenes, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.本發明提供作為V1a受體調節劑且具體而言是作為V1a受體拮抗劑之4H,6H-5-氧雜-2,3,10b-三氮雜-苯并[e]薁、該等製備、含該等之醫藥組合物及該等作為藥劑之用途。本發明之活性化合物係作為作用在神經末梢及中樞之以下病況之治療劑：痛經、男性或女性性功能障礙、高血壓、慢性心臟衰竭、升壓素分泌不當、肝硬化、腎病症候群、焦慮症、抑鬱症、強迫症、自閉症系列病症、精神分裂症及攻擊性行為。
