O'CONNELL, JAMES PHILIP,PORTER, JOHN ROBERT,LAWSON, ALASTAIR,KROEPLIEN, BORIS,RAPECKI, STEPHEN EDWARD,NORMAN, TIMOTHY JOHN,WARRELLOW, GRAHAM JOHN,ARAKAKI, TRACY LYNN,BURGIN, ALEX BUNTIN,PITT, WILLIAM
申请号：
CA2988516
公开号：
CA2988516A1
申请日:
2015.10.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A new, stable trimeric TNFa structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNFa/TNFR1 interaction. Membrane-bound TNFa is not affected in its ability to signal through TNFR2, and thus the new structure of TNFa may be used in therapies which do not significantly raise the risk of infection or malignancy.
