The present invention includes muscle pain, flatulence, cramps, acne, tender breasts, flatulence, fatigue, reduced concentration, impulsive control, irritability, anxiety, tension, anger, depression, insomnia, and It relates to a method of treating symptoms of PMS and PMDD, including / or rapid fluctuations of mood (mood fluctuations). The method includes the administration of a pharmaceutical composition comprising oxaloacetate, oxaloacetate salt, oxaloacetate, and / or enol-oxaloacetate anhydride. [Selection] Figure 1本発明は、筋肉痛、鼓腸、けいれん、ざ瘡、圧痛のある乳房、鼓腸、疲労、集中力の低下、衝動制御の低下、易刺激性、不安、緊張、怒り、うつ状態、不眠症、及び／又は気分の急激な変動（気分変動）を含む、ＰＭＳ及びＰＭＤＤの症状を治療する方法に関する。本方法は、オキサロアセテート、オキサロアセテート塩、オキサロ酢酸、及び／又は無水エノール－オキサロアセテートを含む薬学的組成物の投与を含む。【選択図】図１
