THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人:
Stacy W. Blain
申请号：
US16075900
公开号：
US20190369104A1
申请日:
2017.02.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compositions and methods for the treatment of malignancy are disclosed. Specifically, the disclosure provides a method for treating cancer comprises assessing tyrosine 88 (Y88) phosphorylation (pY88) levels in p27 in a biological sample comprising cancer cells from a subject, and stratifying pY88 phosphorylation levels as 0, 1, 2 or 3 as compared to pY88 phosphorylation levels observed in control tissues； where a level of 0 indicates no detectable sensitivity to cyclin-dependent kinase 4 (cd4k) inhibition； a level of 1, low or no detectable sensitivity； and a level of 2 or 3, indicates detectable sensitivity to cdk4 inhibition. Further provided is a kit for practicing the method.
