PURPOSE: A sustained release therapeutic agent for treating disk diseases containing biodegradable polymer nanoparticles and a method for manufacturing the same are provided to selectively remove painful nerve of dorsal root ganglia. CONSTITUTION: A sustained release therapeutic agent for treating disk diseases contains biodegradable polymer nanoparticles. The biodegradable nanoparticles are polylactic acid(PLLA), polylactic-glycolic copolymer(PLGA) polycarpropactan(PCL), polyglycolic acid(PGA), polylactic-caprolactan copolymer(PLCL) or polyglycolic-caprolactan copolymer(PGCL). The therapeutic agent further contains fibrin. A method for manufacturing the therapeutic agent comprises: a step of mixing a first solution containing biodegradable polymers, capsaicin and organic solvent and a second solution containing PVA(polyvinyl alcohol) and soluble solvent； a step of treating by ultrasonication to form oil-in-water emulsion； and a step of removing the organic solvent from the emulsion.본 발명은 캡사이신이 포집된 생분해성 고분자 나노입자를 포함하는 것을 특징으로 하는 추간판 질환용 서방성 치료제 및 이의 제조방법에 관한 것이다.
