The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from R1 is H or CH3 R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group aryl or heteroaryl group or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring R3 and R4 are same or different and each independently represents H or halogen R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
