LAURA POLISENO,LEONARDO SALMENA,PIER PAOLO PANDOLFI,YVONNE TAY
申请号：
BR112013026298
公开号：
BR112013026298A2
申请日:
2012.04.12
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oliognucleotides, including locked nucleic acids (LNAs).
