Micro-RNA inhibitors and their uses in disease

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专利权人:

Beth Israel Deaconess Medical Center; Inc.

发明人:

Pandolfi, Pier Paolo,Poliseno, Laura,Tay, Yvonne,Salmena, Leonardo

申请号：

AU2012242761

公开号：

AU2012242761A1

申请日:

2012.04.12

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oliognucleotides, including locked nucleic acids (LNAs).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/