Astrid Rey,Sylvie Lefort,Laurent Fraisse,Jeremy Yethon
申请号:
US14396897
公开号:
US20150086601A1
申请日:
2013.05.06
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided are methods for the treatment or prevention of microbial infections (e.g., nocosomial infection) in which the underlying pathology involves a PNAG-containing microbial bio film. The methods the invention generally involve administering to the subject an effective amount of an antibody that specifically binds to PNAG and disrupt or inhibit formation of PNAG-containing microbial bio films. Such methods are particularly useful for the treatment of nosocomial staphylococcus (e.g., S. epidermidis and S. aureus) infections.