СПОСОБ ПОЛУЧЕНИЯ МОНО- И БИЛИГАНДНЫХ КОМПЛЕКСНЫХ СОЕДИНЕНИЙ ИОНОВ ДВУХВАЛЕНТНЫХ МЕТАЛЛОВ- ЦИНКА, МЕДИ (II) И КАЛЬЦИЯ С ДИГИДРОКВЕРЦЕТИНОМ, ОБЛАДАЮЩИХ УСИЛЕННОЙ АНТИОКСИДАНТНОЙ АКТИВНОСТЬЮ
Федеральное государственное бюджетное образовательное учреждение науки Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук РАН (ИрИХ СО РАН) (RU)
发明人:
Трофимова Наталья Николаевна (RU),Бабкин Василий Анатольевич (RU),Столповская Елена Владимировна (RU)
申请号：
RU2013121728/15
公开号：
RU2013121728A
申请日:
2013.05.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A process for preparing complex compounds with dihydroquercetin zinc ions, copper (II) and calcium possessing enhanced antioxidant activity of the flavonoid natural (+) - dihydroquercetin and various zinc salts, copper (II) and calcium, wherein the salt and dihydroquercetin metals mixed in dry form in the reactor at specified molar ratios (1: 1 → 2), water is added at a temperature of 80 ° C or alcohol or a mixture of water and ethyl alcohol at room temperature at a controlled acidity pH 5,0-7,0 while the reaction I is completed almost immediately - within the first 5 minutes, and the complex compound in a yield of 88-93% was isolated by filtration, washing with water and / or ethyl spirtom.2. A method according to claim 1, characterized in that it allows to obtain complexes having a controlled content of metal ions: for copper ion (II) and calcium monoligandnogo type MLHO and zinc ions - biligandnogo type ML (HO), where M - metal ion, L - ligand - deprotonated digidrokvertsetin.3. A method according to claim 1, characterized in that when carrying out the reaction in ethanol or a mixture of water and heating the reaction mixture with ethyl alcohol not trebuetsya.4. A method according to claim 1, characterized in that during the reaction a mixture of water and an organic solvent amount of the latter is taken from 50 to 80 vol.% 5. A method according to claim 1., Characterized in that in the case of containing the anions of metal salts of strong acids requires bringing the pH value of the solution to 7 by adding the reaction mixture is 3-5% caustic solution (sodium hydroxide or ammonium) salts when used metals containing anions of weak acids, the reaction does not require pH control cf.1. Способ получения комплексных соединений дигидрокверцетина с ионами цинка, меди (II) и кальция, обладающих усиленной антиоксидантной активностью, из природного флавоноида (+)-дигидрокверцетина и различных солей цинка, меди (II) и кальция, отличающийся тем, что дигидрокверцетин и со
