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CRISTAL D'UN DÉRIVÉ D'ACÉTAMIDE D'HÉTÉROCYCLIDÈNE
专利权人:
Mochida Pharmaceutical Co.; Ltd.
发明人:
申请号:
EP18810263.6
公开号:
EP3636640A1
申请日:
2018.05.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention provides a type I crystal of (E)-2-(7-trifluoromethyl-chroman-4-ylidene)-N-((7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide having excellent TRPV1 antagonistic activity, a drug and a pharmaceutical composition containing this crystal, and a method for producing the crystal. The present invention provides a type I crystal of (E)-2-(7-trifluoromethyl-chroman-4-ylidene)-N-((7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide that is excellent in at least one feature selected from the group consisting of storage stability, photostability and thermodynamic stability, that can be preferably obtained with industrially high reproducibility, yield and purity, and that is useful as a crystal of an active pharmaceutical ingredient.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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