An oral pharmaceutical composition comprising a drug and one or morepharmaceutically acceptable excipients ina monolithic dosage form, wherein the dosage form is configured such that whenthe dosage form is divided into more than onepiece and at least one of the pieces is administered to a subject the Cmax,AUC, and/or rate of drug released after administration issubstantially the same or lower and the Tmax is higher than the Cmax, AUC,rate of drug released, and/or Tmax after administrationof: (1) a comparable composition in intact dosage form of equal drug dosage ofthe administered at least one piece； (2) abioequivalent drug composition in an intact dosage form of equal drug dosageto the administered at least one piece； and (3) a dividedpiece of a bioequivalent drug composition, wherein the divided piece comprisesa drug dosage equal to the dosage of the administeredpiece of the oral composition. Methods of making the same and methods of usingthe same are also provided.
