The present invention relates to the associated proteins for suppressing VEGF A acceptor interactions.The present invention relates to the associated proteins special to VEGF A, more particularly to the recombinant binding protein including binding structural domain, it suppresses VEGF Axxx combinations VEGFR 2.This kind of protein-bonded example is to include the albumen of the ankyrin repeat domains with required binding specificity.The associated proteins can be used for cancer and the treatment of other pathological conditions, such as illness in eye such as AMD.