Holger Gerhardt;Andrea Emma Lundkvist;Yatin Patel;Salman Rahman
发明人:
Salman Rahman,Yatin Patel,Holger Gerhardt,Andrea Emma Lundkvist
申请号：
US12934541
公开号：
US09040049B2
申请日:
2009.03.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or angiogenesis and endothelial cell proliferation. The invention relates to antibodies and antigen-binding fragments thereof with specificity towards the metalloprotease domain of ADAM 15 and to immunogenic peptide(s) that elicits such antibodies. The invention also relates to compositions and kits comprising the antibodies and immunogenic peptide(s) of the invention, as well as methods and uses of the antibodies and antigen-binding fragments thereof and immunogenic peptide(s), as well as siRNA molecules.
