DUFFEY, Matthew O.,ENGLAND, Dylan,FREEZE, Scott,HU, Zhigen,LANGSTON, Steven P.,MCINTYRE, Charles,MIZUTANI, Hirotake,ONO, Koji,XU, He
申请号：
LT15815330
公开号：
LT3164130T
申请日:
2015.06.30
申请国别(地区):
LT
年份:
2019
代理人:
摘要：
Disclosed are chemical entities which are compounds of formula ():or pharmaceutically acceptable salts thereof； wherein Y, R, R, R, R, X, X, X, R, Z, and Zhave the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.
