Matthew O. Duffey,Dylan England,Brian Scott Freeze,Zhigen Hu,Steven Langston,Charles McIntyre,Hirotake Mizutani,Koji Ono,He Xu
申请号：
US16391534
公开号：
US10780090B2
申请日:
2019.04.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed are chemical entities which are compounds of formula (I):or pharmaceutically acceptable salts thereof； wherein Y, Ra, Ra′；, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.
