Je-Yong Choi;Young-Hyun Hwang;In-Kyeom Kim;Kyung Eun Lim;Jae-Hwan Jeong;Min-su Han;Yong-Hoon Kim
发明人:
Je-Yong Choi,Min-su Han,Jae-Hwan Jeong,Kyung Eun Lim,Yong-Hoon Kim,Young-Hyun Hwang,In-Kyeom Kim
申请号：
US13643597
公开号：
US20130085178A1
申请日:
2011.04.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method for preventing or treating a bone disease, includes administering to a patient having the bone disease a pharmaceutical composition comprising glyceollin as an active ingredient. The active ingredient, glyceollin promotes degradation of the Runx2 protein in osteoblasts and inhibits the mRNA expression of Rankl in osteoblasts to prevent the differentiation of osteoclasts. Furthermore, glyceollin is capable of ameliorating osteoporosis in animal models for osteoporosis. The composition promises drug or food for prevention or treatment of not only osteoporosis but also bone diseases caused by cancer metastatic to the bone.
