A system targeted neurogenesis stimulated by aerobic exercise with virtual reality enhanced brain function specific tasks. A user may participate in virtual reality tasks that challenge specific brain functions has been developed. This system comprises a targeted neurogenesis virtual reality server, an aerobic exercise machine, input devices for interaction with the virtual reality environment, and a virtual reality display device. The targeted neurogenesis virtual reality server selects virtual reality interaction configurations specifically designed to repetitively challenge one of more brain functions while maintaining maximal user attention. The aerobic exercise machine promotes engagement in an exercise plan and monitors physiological data to maintain level of intensity within pre-programmed range.
