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치환된 인돌, 항바이러스 활성 성분, 이의 제조방법 및 이의 용도
专利权人:
ALLA CHEM; LLC
发明人:
IVACHTCHENKO ALEXANDRE VASILIEVICH,이바센코, 알렉산드레 바실리에비치,BICHKO VADIM VASILIEVICH,비쉬코, 바딤 바실리에비치,MITKIN OLEG DMITRIEVICH,밋킨, 올레그 디미트리비치
申请号:
KR1020137004606
公开号:
KR1020130045912A
申请日:
2011.07.19
申请国别(地区):
KR
年份:
2013
代理人:
摘要:
The invention relates to novel antiviral active components of the general formula 1, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatisis C viruses (HCV). In the general formula 1 R1 represents hydrogen, optionally substituted C 1 -C 4 alkyl, C 6 cycloalkyl, aryl, ethoxycarbonyl, nitro group R2 represents hydrogen R3 represents N -mono-or N,N -disubstituted 1-methylene-piperidine-3-carboxamide of the general formula 1a or N -mono- or N,N -disubstituted 1-methylene-piperidine-4-carboxamide of the general formula 1b R4 represents hydrogen, optionally substituted C 1 -C 3 alkyl or R2 and R3 together with the C-atoms they are attached to form substituted ,3,4,9-tetrahydro-1 H -carbazole of the general formula 1.1, or R2, R3, and R4 together with the atoms they are attached to form substituted azaheterocycles of the eneral formula 1.2 R5 and R6 optionally identical represent hydrogen, optionally substituted C 1 -C 3 alkyl or C 3 -C 6 cydoalkyl, or R5 and R6 together with the N-atom they are attached to form optionally substituted 5- or 6- membered azaheterocyclyl comprising one or two N-atoms and optionally condensed with benzene ring R7 and R8 represent hydrogen or R7 and R8 together with the C-atom they are attached to form C=O group R9 represents azaheterocyclyl comprising at least one N-atom, unsubstituted formamide, or phenyl substituted with ethoxycarbonyl or nitro group R10 represents hydrogen, optionally substituted C 1 -C 3 alkyl, substituted acetyl n = 1 or 2 solid line accompanied by the dotted line, i.e. ( ), represents single or double C-C bond.본 발명은 화학식 1의 신규한 항바이러스 활성 성분, 약학적 조성물, 항바이러스 약물, 바이러스성 질환, 특히 C형 간염 바이러스 (HCV)에 의해 발병되는 질환의 예방 및 치료 방법에 관한 것이다,R1은 수소, 임의적으로 치환된 C1-C4 알킬, C6 사이클로알킬, 아릴, 에톡시카르보닐, 나이트로기이고 R2는 수소이고 R3은 화학식 1a의 N-모노- 또는 N,N-이중 치환된 1-메틸렌-피페리딘-3-카르복스아마이드 또는 N-모노- 또는 N,N-이중 치환된 화학식 1b의 1-메틸렌-피페리딘-4-카르복
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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