Porous calcium phosphate granules and methods of making the same are provided. Embodiments of the methods include producing a solid spherical granule precursor that includes: (i) a calcium phosphate component and (ii) a porogen component and (b) removing the porogen component from the solid spherical granule precursor to produce a spherical porous calcium phosphate granule. Granules of the invention find use in a variety of different applications.
