1. A tetracycline compound having the following formula: wherein: J 5 and J 6 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, sulfonyl, acyl, substituted carbonyl or substituted thiocarbonyl, or linked to form a ring; J 7 and J 8 are each alkyl, halogen, or hydrogen; and R 7 is hydrogen, or pharmaceutically acceptable salts thereof.