A Luer securement device (10) comprising a Luer adapter (70) having a septum (80) and a catheter hood (72), the Luer adapter further having a wedge seal (82) for receiving a base portion (92) of a catheter (90). The Luer securement device further includes an inserter body (20) in which is slidably housed a catheter threader (50) having a probe (53) which is configured to advance the base portion of the catheter through the septum thereby seating the base portion of the catheter into the wedge seal of the Luer adapter as a tip portion of the catheter is inserted into a patient. The catheter threader further includes a needle adapter (100) having a needle which is threaded through the probe and the catheter to assist in inserting the catheter into the patient. Following insertion of the catheter, the catheter threader is retracted within the inserter body thereby withdrawing the needle from the catheter and shielding a sharpened tip of the needle within at least one of the inserter body and the catheter threader. The inserter body is then detached from the Luer adapter and discarded.
