A balloon catheter (20) with delivery probe is provided. The catheter (22) has a balloon (24), a first lumen (26) and a probe (28) movably disposed in the first lumen of said catheter. The probe has a lumen (34) for delivering a diagnostic and/or therapeutic agent to tissue. The catheter has a third lumen through which fluid is supplied to the balloon. The catheter with delivery probe may be inserted into a bodily cavity such that the distal end of the probe extends out of an opening (30) in the catheter. When the balloon is inflated the probe is captured between an outer wall of the balloon and the tissue so that therapeutic and/or diagnostic agent may be delivered to the tissue through the probe lumen via the distal end of the probe. Furthermore, two additional balloons (224, 202) disposed distally and proximally of the balloon to create a chamber.
