STASI, Luigi Piero,ROVATI, Lucio Claudio,ARTUSI, Roberto,COLACE, Fabrizio,MANDELLI, Stefano,PERUGINI, Lorenzo
申请号：
ES12812248
公开号：
ES2624209T3
申请日:
2012.12.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula (I) or stereoisomer, or racemate or pharmaceutically acceptable mixture or salt thereof: ** Formula ** in which: R is a derivative of phenyl, thiazolin-4-yl or pyridin-2-yl, in the that said derivatives are substituted with n groups Q； Q is selected from the group consisting of: C1-C4 alkyl, halogen, C1-C4 haloalkyl, C1-C4 alkoxy, CN, SO2CH3 or a group -O [(CR1R2] pQ1； or Q may be a group Q2； Q1 is phenyl, which may be optionally substituted with n substituents selected from the group consisting of: C1-C4 alkyl, halogen, C1-C4 haloalkyl, C1-C4 alkoxy, CN or a Q2 group； or Q1 corresponds to 2,2-difluorobenzo [ d] [1,3] dioxol-4-yl； Q2 is a 5- or 6-membered heteroaryl containing at least one nitrogen atom, which may be optionally substituted with n substituents selected from the group consisting of: C1-C4 alkyl , halogen, C1-C4 haloalkyl, C1-C4 alkoxy and CN； P is a 6-membered heteroaryl or an 8-11 membered bicyclic heteroaryl group, which may be substituted with n substituents selected from the group consisting of: C1- alkyl C4, halogen, C1-C4 haloalkyl, C1-C4 alkoxy and CN； R1 is hydrogen or C1-C3 alkyl； R2 is hydrogen or C1-C3 alkyl； n is 1, 2 or 3； p is 0, 1 or 2； and with the proviso that when R corresponds to phenyl substituted with n Q groups, P is a pyridinyl derivative substituted with at least one CF3 group.Compuesto de fórmula (I) o estereoisómero, o racemato o mezcla o sal farmacéuticamente aceptable del mismo:**Fórmula** en la que: R es un derivado de fenilo, tiazolin-4-ilo o piridin-2-ilo, en el que dichos derivados están sustituidos con n grupos Q； Q se selecciona del grupo que consiste en: alquilo C1-C4, halógeno, haloalquilo C1-C4, alcoxilo C1-C4, CN, SO2CH3 o un grupo -O[(CR1R2]pQ1； o Q puede ser un grupo Q2； Q1 es fenilo, que puede estar opcionalmente sustituido con n sustituyentes seleccionados del grupo que consiste en: alquilo C1-C4, halógeno, haloalquilo C1-C4, alcoxilo C1-C4, CN o un grupo Q2； o Q1 corresponde a 2,2-difluoro
