The yeast organic zinc dentifrice composition of the present invention includes a dental plaque removing component, an anti-allergic component, an oral odor removing component, an abrasive component, a thickener component, an anionic surfactant component and a foaming agent group Minute. Wherein, the dental plaque removal component includes yeast organic zinc prepared by reaction of yeast and zinc gluconate. The invention also provides a method for preparing the yeast organic zinc dentifrice composition. The yeast organic zinc dentifrice composition has better plaque removal effect and whitening effect, and has low sensitivity to teeth and oral cavity.本發明酵母有機鋅牙粉組成物,包含牙菌斑去除組分、抗敏組分、口腔異味去除組分、研磨劑組分、增稠劑組分、陰離子界面活性劑組分及起泡劑組分。其中,該牙菌斑去除組分包括由酵母菌與葡萄糖酸鋅經反應所製得的酵母有機鋅。本發明也提供一種酵母有機鋅牙粉組成物的製備方法。該酵母有機鋅牙粉組成物具有較佳的牙菌斑去除效果及美白效果,且對牙齒及口腔的致敏感性低。