METHOD OF TREATING DEMYELINATING DISEASE
- 专利权人:
- THE HOSPITAL FOR SICK CHILDREN
- 发明人:
- MASTRONARDI, FABRIZIO,MOSCARELLO, MARIO A.,WOOD, DENISE
- 申请号：
- CA2758829
- 公开号：
- CA2758829C
- 申请日:
- 2009.04.17
- 申请国别(地区):
- CA
- 年份:
- 2018
- 代理人:
- 摘要：
- A method of inhibiting Peptidyl Argininedeiminase (PAD) in a mammal isprovided wherein said method comprisesthe step of administering 2-haloacetamidine to a mammal. The method is usefulto treat a demyelinating disease in mammalssuch as multiple sclerosis, as well as other diseases in which hyper-citrullination is a factor. Pharmaceutical compositions useful totreat said disease are also provided, as well as a method of screening for PADinhibitors.
- 来源网站：
- 中国工程科技知识中心
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