БАРНЕУ Паскаль (FR),БЛАНШАР-БРЕЖОН Вероник (FR),ДЭЛЕ-ГУАЙЕ Филипп (FR),МАРИ Вероник (FR),МЕНАЖЕ Жан (FR),ЛОПЕС ГРАНЧА Матильда (FR),РУНИ Томас (FR),ШУССЛЕР Натали (FR)
申请号：
RU2014144615
公开号：
RU2014144615A
申请日:
2013.04.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound, 2- (cyclohexylmethyl) -N- {2 - [(2S) -1-methylpyrrolidin-2-yl] ethyl} -1,2,3,4-tetrahydroisoquinoline-7-sulfonamide or a pharmaceutically acceptable salt thereof, for use in preventing or slowing the progression of the disease in the case of tauopathy or a related neurodegenerative disease in a patient. 2. A compound for use according to claim 1, wherein the patient inhibits abnormal tau hyperphosphorylation or abnormal tau aggregation. 3. A compound for use according to claim 1, wherein the level of phosphorylated tau protein in said patient with tauopathy or a related neurodegenerative disease is reduced. The compound for use according to claim 1, wherein the formation of neurofibrillary nodes in the specified patient is inhibited. A compound for use according to claim 1, wherein the level of neurofibrillary nodes in the neuron in the specified patient is inhibited. The compound for use according to claim 1, wherein the cytoskeleton dysfunction or perturbation of other tau-dependent functions slows down or stops. A compound for use according to claim 1, wherein the level of phosphorylated tau protein and tau protein in the cerebrospinal fluid of the patient is reduced. A compound for use according to claim 1, wherein the tau aggregates of said patient are destroyed or disintegrated. A compound for use according to claim 1, wherein said patient inhibits or decreases the phosphorylation of the tau protein in the neuron, glial cell, or Levi body. A compound for use according to claim 9, wherein the tau protein is a microtubule-associated tau protein. A compound for use according to claim 10, wherein the tau protein is located in a neurofibrillar node. Connection for1. Соединение, 2-(циклогексилметил)-N-{2-[(2S)-1-метилпирролидин-2-ил]этил}-1,2,3,4-тетрагидроизохинолин-7-сульфонамид или его фармацевтически приемлемая соль, для применения в целях предотвращения или замедления прогрессирования заболевания в случае таупатии или родственного нейродегенера
