PROBLEM TO BE SOLVED: To provide a tauopathy progression inhibitor for inhibiting the accumulation of tau protein.SOLUTION: The present invention provides a tau protein phosphorylation inhibitor that exists as a ferulic acid ester or glycoside in the cell wall of a plant, such as rice or wheat, or a seed thereof and includes extracted, isolated, purified, or chemically synthesized ferulic acid (3-methoxy-4-hydroxybenzene acrylic acid) as an active ingredient, and a nerve cell death inhibitor by phosphorylated tau protein.EFFECT: The reduced nerve cell protein phosphatase PP2A is activated, the phosphorylation of tau protein is suppressed, and as a result, nerve cell death is suppressed, and the progression of tauopathy, such as Alzheimers disease, is suppressed.SELECTED DRAWING: Figure 3COPYRIGHT: (C)2017,JPO&INPIT【課題】タウ蛋白質の蓄積を抑制しうるタウオパチーの進行抑制剤の提供。【解決手段】米、小麦等の植物や種子の細胞壁中フェルラ酸エステルや配糖体として存在し、抽出・単離・精製若しくは化学的に合成したフェルラ酸(3-メトキシ-4-ヒドロキシベンゼンアクリル酸)を有効成分とするタウ蛋白質のリン酸化抑制剤、及びリン酸化タウ蛋白質による神経細胞死抑制剤。【効果】低下した神経細胞のプロテインフォスファターゼPP2Aが活性化され、タウ蛋白質のリン酸化が抑制され、その結果、神経細胞死が抑制され、アルツハイマー病等のタウオパチーの進行が抑制される。【選択図】図3
