DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME
VERNIER, JEAN-MICHEL,ROWLINGS, COLIN, EDWARD,GIRARDET, JEAN-LUC,DIMOCK, STUART,QUART, BARRY,MINER, JEFFREY, N
申请号：
NZ58292908
公开号：
NZ582929A
申请日:
2008.07.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the use of a compound of formula (I) where the substituents are as disclosed in the specification in the manufacture of a medicament. Particular compounds are N-(3,4,6-trifluoro-2-(2-fluoro-4-iodophenylamino)-phenyl)-1-(2,3-dihydroxypropyl) cyclopropane-1-sulfonamide and N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl) cyclopropane-1-sulfonamide. Also disclosed in the compound, composition, or polymorph comprising one of the particular compounds a batch of tablets comprising a particular compound and a method of treating cancer or inhibiting MEK enzymes wherein the method is not in a human. The medicament is useful for inhibiting MEK enzymes as treating disorders such as stroke, cancer and inflammatory diseases.
