CORN, JACOB, E.,ZHANG, YINGNAN,PHILLIPS, AARON, H.
申请号：
EP12871585
公开号：
EP2825549A4
申请日:
2012.06.19
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.
