Thorsten MUTZKE,Markus KREUZ,Stefanie SEWING,Fabian Johannes EBER,Wenke WAGNER,Michael SONNTAG,Michael WIGGENHORN,Katharina KOLLAND
申请号：
US15566010
公开号：
US20180214537A1
申请日:
2016.04.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.
