DERIVE DE MONOQUINOLINE DE CHELATION TETRADENTATE, SON PROCEDE DE FABRICATION ET SON APPLICATION EN TANT QUE REGULATEUR D'IONS METALLIQUES POUR LES MALADIES NEURODEGENERATIVES

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专利权人:

GUANGDONG UNIVERSITY OF TECHNOLOGY;THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人:

LIU, YAN,ZHANG, WEIXIN,HUANG, DAYA,HUANG, MEIJIE,WANG, DEAN,HUANG, JU,SHU, SIWEI,NGUYEN, MICHEL,ROBERT, ANNE,MEUNIER, BERNARD,LIU, XINGGUO

申请号：

CA3025406

公开号：

CA3025406A1

申请日:

2017.05.25

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

A tetradentate chelating monoquinoline derivative as represented by formula (I). The derivative can specifically chelate to a redox-active metal ion, such as a copper ion, related to a neurodegenerative disease (Alzheimer's disease, Parkinson's disease, or amyotrophic lateral sclerosis) or metabolic disorder, or to a copper accumulation disease (Wilson's disease). A zinc ion stability constant of the derivative is 6-12 orders of magnitude lower than a copper ion stability constant thereof. The derivative also has stronger oxidative stress resistance. The derivative is easy to manufacture, and has potential applications in preparing a pharmaceutical product for treating a neurodegenerative disease or a pharmaceutical product for a disease related to a copper homeostasis disorder.

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