The invention features echinocandin class compounds that have been modified to (i) have activity against one or more fungal species or genera (ii) have increased aqueous solubility (iii) have an increased therapeutic index (iv) be suitable for topical administration and/or (v) be suitable for oral administration. The echinocandin class compounds of the invention include, for example, a PEG, alkyl-PEG, aryl-PEG, alkaryl-PEG, PEG-alkyl, PEG-aryl, or PEG-alkaryl substituent.
