Frédéric Gilbert LABÉGUÈRE,Gregory John Robert NEWSOME,Luke Jonathan ALVEY,Laurent Raymond Maurice SANIÈRE,Stephen Robert FLETCHER
申请号：
US13721788
公开号：
US20130165437A1
申请日:
2012.12.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A compound according to Formula Ia:wherein L1, G, and R1 are as described herein.The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
