MICHAEL MUTZ,マッツ，ミハエル,GUIDO JORDINE,ジョルディン，グイド,マッツ,ミハエル,ジョルディン,グイド
申请号：
JP2015173474
公开号：
JP2016028056A
申请日:
2015.09.03
申请国别(地区):
JP
年份:
2016
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide hydrates of novel crystalline forms of FTY720, which is a compound effective in treatment of organ or tissue transplant rejection, autoimmune diseases or inflammatory conditions, and pharmaceutical compositions containing the hydrates of the crystalline forms.SOLUTION: The present invention relates to: hydrates of FTY720 [2-amino-2-(2-(4- octylphenyl)ethyl)propane-1,3-diol] hydrochloride represented by the formula in the figure, whose X-ray powder diffraction pattern includes peaks at about 2.9, 17.2, 30.6, 28.2, 24.4, 8.6 and 25.9 degrees 2&thetas；； and pharmaceutical compositions containing the hydrates of FTY720 hydrochloride. The water contents of the hydrates are preferably 5.2 to 10.6%.SELECTED DRAWING: None【課題】臓器移植もしくは組織移植の拒絶、自己免疫疾患又は炎症状態の治療に有効な化合物ＦＴＹ７２０の新規結晶形の水和物、及び該結晶形の水和物を含む医薬組成物の提供。【解決手段】Ｘ線粉末回折パターンが、２．９、１７．２、３０．６、２８．２、２４．４、８．６及び２５．９度の２θのピークを含む、下式で示されるＦＴＹ７２０［２－アミノ－２－（２－（４－オクチルフェニル）エチル）プロパン－１，３－ジオール］塩酸塩の水和物、及び該ＦＴＹ７２０塩酸塩の水和物を含む医薬組成物。該水和物の水含有率は、５．２～１０．６％であることが好ましい。【選択図】なし
