POLYTHERAPIE AU CENICRIVIROC POUR LE TRAITEMENT DE LA FIBROSE

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专利权人:

INC.;TOBIRA THERAPEUTICS

发明人:

LEFEBVRE, ERIC

申请号：

CA2960284

公开号：

CA2960284A1

申请日:

2015.09.11

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Cenicriviroc (CVC) is an orally active antagonist of ligand binding to C-C chemokine receptor type 5 (CCR5) and C-C chemokine receptor type 2 (CCR2). CVC blocks the binding of RANTES, MIP-1a, and MIP-1ß to CCR5, and of MCP-1/CCL2 to CCR2. Methods of treating fibrosis and related conditions comprising co-administration of CVC with FXR agonists, high dose vitamin E (>； 400 iU/d), a peroxisome proliferator-activated receptor alpha (PPAR-a) agonist, PPAR-? agonist, PPAR-d agonist and/or chemokine antagonists are provided herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/